A New Jersey native, Tyree was selected in the sixth round of the 2003 NFL draft by the Giants out of Syracuse University. He would play sparingly in his rookie season, catching 16 passes for 211 yards.
Over the next few seasons, Tyree filled in admirably when needed. He was most needed however, during the Giants' Super Bowl game against the New England Patriots. And he came through with one of the greatest receptions in New York Giant history.
With the Giants trailing the Patriots by a score of 14-10, and 1:15 remaining in the game, the Giants had the ball on third down. Quarterback Eli Manning escaped the Patriots defenders and heaved the ball downfield, where it found David Tyree in tight coverage. Tyree grasped the ball against his helmet, falling to the ground for a game-saving catch. The Giants would, of course, go on to win that Super Bowl by a score of 17-14.